Recombinant HEK293 SOST
Eton Bio Recombinant Human Sclerostin is produced by our mammalian expression system. The target protein is expressed with sequence (Gln24-Tyr213) of Human SOST with a polyhistidine tag at the C-terminus.
Sclerostin, also known as SOST, is a member of the Cerberus/DAN family of BMP antagonists. SOST is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain. It shows sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. SOST is produced by the osteocyte and has anti-anabolic effects on bone formation. It is a negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation.
|Names||SOST, UNQ2976, PRO7455, PRO7476|
|Formulation||Supplied as a 0.2 μM filtered solution of 20mM Tris, 250mM NaCl, pH 8.0|
|Shipping||The product is shipped on dry ice/ice packs.
|Storage||Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.
|Purity||Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.
|Endotoxin||Less than 0.1 ng/µg (1 IEU/µg).|
|Amino Acid Sequence||
QGWQAFKNDATEIIPELGEYPEPPPELENNKTMNRAENGGRPPHHPFETKDVSEYSCRELHFTRY VTDGPCRSAKPVTELVCSGQCGPARLLPNAIGRGKWWRPSGPDFRCIPDRYRAQRVQLLCPGGEA PRARKVRLVASCKCKRLTRFHNQSELKDFGTEAARPQKGRKPRPRARSAKANQAELENAYHHHHH H