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- Lapatinib Ditosylate
Lapatinib Ditosylate
Lapatinib is a potent inhibitor of EGFR kinase (Ki = 3 nM), ErbB-2 kinase (Ki = 13 nM), ErbB-4 kinase (Ki = 347 nM). Lapatinib can restore tamoxifen sensitivity in tamoxifen-resistant, ER-positive breast cancer models.
| Molecular Formula: | C29H26ClFN4O4S•2C7H8O3S |
| Molecular Weight: |
925.46 g/mol |
| CAS Number: | 388082-78-8 |
| Apperance: | Pale yellow to yellow powder
|
| Solubility: | Soluble in DMSO at 200 mg/mL; very poorly soluble in ethanol |
| Purity: | ≥99% |
| Storage: | -20ºC |
MATERIAL SAFETY DATA SHEET
TRADENAME: Lapatinib Ditosylate
DATE OF ISSUE:Feb 10.2011
SKU#:1100181002(100mg), 1100182002(200mg), 1100183002(300mg), 1100180013(1g), 1100180023(2g)
SECTION I:PRODUCT AND MANUFACTURER INFORMATION
TRADE NAME: Lapatinib Ditosylate
Supplier: Eton Bioscience Inc., 5820 Oberlin Drive, Suite 108, San Diego, CA 92121
Information Telephone:800.758.1630
Emergency Telephone: 800.758.1630
SECTION II: COMPOSITION / INFORMATION ON INGREDIENTS
Chemical Name: N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine Ditosylate
Synonyms:
Hazardous Ingredient: Lapatinib Ditosylate
Synonyms:
Hazardous Ingredient: Lapatinib Ditosylate
Molecular Weight: 925.46
Molecular Formula: C29H26ClFN4O4S•2C7H8O3S
Molecular Formula: C29H26ClFN4O4S•2C7H8O3S
CAS Number: 388082-78-8
SECTION III:HAZARD IDENTIFICATION
Hazard Description: may be an irritant
Exposure may cause irritation to eyes, skin, mucous membranes, and upper respiratory tract
Ingestion may result in diarrhea, nausea, abdominal cramping, rash, and fatigue
Exposure may cause irritation to eyes, skin, mucous membranes, and upper respiratory tract
Ingestion may result in diarrhea, nausea, abdominal cramping, rash, and fatigue
SECTION IV:FIRST AID MEASURES
After Inhalation: If inhaled, remove to fresh air; if breathing is difficult, give oxygen; if breathing stops, give artificial respiration
After skin contact: flush with copious amounts of water; remove contaminated clothing and shoes; call a physician
After eye contact: check for and remove contact lenses and flush with copious amounts of water; assure adequate flushing by separating the eyelids with fingers; call a physician
After swallowing: if swallowed, wash out mouth with copious amounts of water; call a physician
After skin contact: flush with copious amounts of water; remove contaminated clothing and shoes; call a physician
After eye contact: check for and remove contact lenses and flush with copious amounts of water; assure adequate flushing by separating the eyelids with fingers; call a physician
After swallowing: if swallowed, wash out mouth with copious amounts of water; call a physician
SECTION V:FIREFIGHTING MEASURES
Suitable extinguishing agents: water spray, carbon dioxide, dry chemical powder or foam
Protective equipment: wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Unusual fire hazard: none known
Protective equipment: wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Unusual fire hazard: none known
SECTION VI:ACCIDENTAL RELEASE MEASURES
Person-related safety precautions: cordon off area of spill; wear self-contained breathing apparatus, protective clothing and heavy rubber gloves
Measures for cleaning/collecting: absorb solutions with finely-powdered liquid-binding material (diatomite, universal binders); decontaminate surfaces and equipment by scrubbing with alcohol; dispose of contaminated material according to Section 13
Measures for cleaning/collecting: absorb solutions with finely-powdered liquid-binding material (diatomite, universal binders); decontaminate surfaces and equipment by scrubbing with alcohol; dispose of contaminated material according to Section 13
SECTION VII:HANDLING AND STORAGE
Information for safe handling: avoid inhalation and contact with skin, eyes and clothing; material may be an irritant
Storage: store solid and solutions at -20 ºC
Storage: store solid and solutions at -20 ºC
SECTION VIII:EXPOSURE CONTROLS / PERSONAL PROTECTION
Personal protective equipment as follows:
Breathing equipment: NIOSH/MSHA-approved respirator
Protection of hands: chemical-resistant rubber gloves
Eye protection: chemical safety goggles
Breathing equipment: NIOSH/MSHA-approved respirator
Protection of hands: chemical-resistant rubber gloves
Eye protection: chemical safety goggles
SECTION IX:PHYSICAL AND CHEMICAL PROPERTIES
Form: crystalline solid; granular or powder
Color: yellow
Odor: none
Melting point/Melting range: 241-252 ºC
Danger of explosion: none
Solubility in / Miscibility with water: very poorly soluble in water; maximum solubility in plain water is estimated to be about 1-10 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility
Solvent content: none
Organic solvents: Soluble in DMSO at 200 mg/mL; very poorly soluble in ethanol
Color: yellow
Odor: none
Melting point/Melting range: 241-252 ºC
Danger of explosion: none
Solubility in / Miscibility with water: very poorly soluble in water; maximum solubility in plain water is estimated to be about 1-10 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility
Solvent content: none
Organic solvents: Soluble in DMSO at 200 mg/mL; very poorly soluble in ethanol
SECTION X:STABILITY AND REACTIVITY
Stability: stable if stored as directed; avoid strong oxidizing agents
Thermal decomposition / conditions to be avoided: protect from light and heat
Dangerous products of decomposition: thermal decomposition may produce toxic gases such as carbon monoxide, carbon dioxide, and nitrogen oxides
Thermal decomposition / conditions to be avoided: protect from light and heat
Dangerous products of decomposition: thermal decomposition may produce toxic gases such as carbon monoxide, carbon dioxide, and nitrogen oxides
SECTION XI:TOXICOLOGICAL INFORMATION
RTECS #: not available
Acute toxicity: none known
Primary irritant effect: none known
On the skin: none known; may be an irritant
On the eye: not known; may be an irritant
Inhalation: not known; may be an irritant
Ingestion: may result in adverse gastrointestinal effects
Acute toxicity: none known
Primary irritant effect: none known
On the skin: none known; may be an irritant
On the eye: not known; may be an irritant
Inhalation: not known; may be an irritant
Ingestion: may result in adverse gastrointestinal effects
SECTION XII:ECOLOGICAL INFORMATION
General notes: no data available
SECTION XIII:DISPOSAL CONSIDERATIONS
Dispose of in accordance with prevailing country, federal, state and local regulations
SECTION XIV:TRANSPORT INFORMATION
DOT:
Proper shipping name: none
Non-Hazardous for transport: this substance is considered to be non-hazardous for transport
IATA class:
Proper shipping name: none
Non-Hazardous for transport: this substance is considered to be non-hazardous for transport
Proper shipping name: none
Non-Hazardous for transport: this substance is considered to be non-hazardous for transport
IATA class:
Proper shipping name: none
Non-Hazardous for transport: this substance is considered to be non-hazardous for transport
SECTION XV:REGULATORY INFORMATION
Code letter and hazard designation of product:
EU Risk And Safety phrases:
S22: Do not breathe dust
S24/25: Avoid contact with skin and eyes
S36/37: Wear suitable protective clothing and gloves
EU Risk And Safety phrases:
S22: Do not breathe dust
S24/25: Avoid contact with skin and eyes
S36/37: Wear suitable protective clothing and gloves
SECTION XVI:OTHER INFORMATION
The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty ofn merchantability or any other warranty, express or implied, with respect to such information. Eton Bioscience Inc. shall not be held liable for any damages or other consequences resulting from handling or from contact with the above product.
END OF DATASHEET
