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Dasatinib
Dasatinib is a multikinase inhibitor with potent activity against BCR–ABL kinase (IC50 <1 nM) and SFKs (IC50 of 0.2–1.1nM) that has been approved by the US Food and Drug Administration (FDA) for the treatment of patients with CML following failure or with intolerance to imatinib therapy. Small molecule inhibitor of both the SRC and BCR/ABL tyrosine kinases, with IC50's for the isolated kinases of 0.55 and 3.0 nM, respectively. Dasatinib also inhibits Lyn (IC50 = 8.5 nM) and Src (IC50 = 3.0 nM) kinase activities in vitro using 0.1 mg/mL poly (Glu4-Tyr) as the substrate. Dasatinib has greater potency than imatinib mesylate and has activity against the majority of kinase mutations in imatinib-resistant chronic myeloid leukemia.
| Molecular Weight: | 488.01 g/mol |
| Molecular Formula: | C22H26CIN7O2S |
| CAS Number: | 302962-49-8 |
| Solubility in / Miscibility with water: | very poorly soluble in water; maximum solubility in plain water is estimated to be about 10 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility |
| Organic solvents: | soluble in DMSO at 200 mg/mL; very poorly soluble in ethanol |
| Purity: |
≥99% |
| Storage: | -20C |
MATERIAL SAFETY DATA SHEET
TRADENAME:Dasatinib
DATE OF ISSUE:Feb 10.2011
SKU#:1100145002(500mg), 1100140013(1g), 1100140023(2g), 1100140053(5g), 1100140103(10g)
SECTION I:PRODUCT AND MANUFACTURER INFORMATION
TRADE NAME: Dasatinib
Supplier: Eton Bioscience Inc., 5820 Oberlin Drive, Suite 108, San Diego, CA 92121
Information Telephone:800.758.1630
Emergency Telephone: 800.758.1630
SECTION II: COMPOSITION / INFORMATION ON INGREDIENTS
Chemical Name: Dasatinib
Synonyms:
Hazardous Ingredient: Dasatinib
Molecular Weight: 488.01
Molecular Formula: C22H26CIN7O2S
Synonyms:
Hazardous Ingredient: Dasatinib
Molecular Weight: 488.01
Molecular Formula: C22H26CIN7O2S
CAS Number: 302962-49-8
SECTION III:HAZARD IDENTIFICATION
Hazard Description: Toxic
May cause serious health effects if swallowed
May be harmful to fetus
Target organs: Gastrointestinal tract, blood, embryo/fetus
May be an irritant; exposure may cause irritation to eyes, skin, mucous membranes, and upper respiratory tract
May cause serious health effects if swallowed
May be harmful to fetus
Target organs: Gastrointestinal tract, blood, embryo/fetus
May be an irritant; exposure may cause irritation to eyes, skin, mucous membranes, and upper respiratory tract
SECTION IV:FIRST AID MEASURES
After Inhalation: If inhaled, remove to fresh air; if breathing is difficult, give oxygen; if breathing stops, give artificial respiration
After skin contact: flush with copious amounts of water; remove contaminated clothing and shoes; call a physician
After eye contact: check for and remove contact lenses and flush with copious amounts of water; assure adequate flushing by separating the eyelids with fingers; call a physician
After swallowing: if swallowed, wash out mouth with copious amounts of water; call a physician
After skin contact: flush with copious amounts of water; remove contaminated clothing and shoes; call a physician
After eye contact: check for and remove contact lenses and flush with copious amounts of water; assure adequate flushing by separating the eyelids with fingers; call a physician
After swallowing: if swallowed, wash out mouth with copious amounts of water; call a physician
SECTION V:FIREFIGHTING MEASURES
Suitable extinguishing agents: water spray, carbon dioxide, dry chemical powder or foam
Protective equipment: wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Unusual fire hazard: none known
Protective equipment: wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Unusual fire hazard: none known
SECTION VI:ACCIDENTAL RELEASE MEASURES
Person-related safety precautions: cordon off area of spill; wear self-contained breathing apparatus, protective clothing and heavy rubber gloves
Measures for cleaning/collecting: absorb solutions with finely-powdered liquid-binding material (diatomite, universal binders); decontaminate surfaces and equipment by scrubbing with alcohol; dispose of contaminated material according to Section 13
Measures for cleaning/collecting: absorb solutions with finely-powdered liquid-binding material (diatomite, universal binders); decontaminate surfaces and equipment by scrubbing with alcohol; dispose of contaminated material according to Section 13
SECTION VII:HANDLING AND STORAGE
Information for safe handling: avoid inhalation and contact with skin, eyes and clothing; material may be an irritant
Storage: Store solid and solutions at -20C
SECTION VIII:EXPOSURE CONTROLS / PERSONAL PROTECTION
Personal protective equipment as follows:
Breathing equipment: NIOSH/MSHA-approved respirator
Protection of hands: chemical-resistant rubber gloves
Eye protection: chemical safety goggles
Breathing equipment: NIOSH/MSHA-approved respirator
Protection of hands: chemical-resistant rubber gloves
Eye protection: chemical safety goggles
SECTION IX:PHYSICAL AND CHEMICAL PROPERTIES
Form: solid powder
Color: off-white to pale yellow
Odor: none
Melting point/Melting range: 261-285 ºC
Danger of explosion: none
Solubility in / Miscibility with water: very poorly soluble in water; maximum solubility in plain water is estimated to be about 10 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility
Solvent content: none
Organic solvents: soluble in DMSO at 200 mg/mL; very poorly soluble in ethanol
Color: off-white to pale yellow
Odor: none
Melting point/Melting range: 261-285 ºC
Danger of explosion: none
Solubility in / Miscibility with water: very poorly soluble in water; maximum solubility in plain water is estimated to be about 10 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility
Solvent content: none
Organic solvents: soluble in DMSO at 200 mg/mL; very poorly soluble in ethanol
SECTION X:STABILITY AND REACTIVITY
Stability: stable if stored as directed; avoid strong oxidizing agents
Thermal decomposition / conditions to be avoided: protect from light and heat
Dangerous products of decomposition: thermal decomposition may produce toxic gases such as carbon monoxide, carbon dioxide, and nitrogen oxides
Thermal decomposition / conditions to be avoided: protect from light and heat
Dangerous products of decomposition: thermal decomposition may produce toxic gases such as carbon monoxide, carbon dioxide, and nitrogen oxides
SECTION XI:TOXICOLOGICAL INFORMATION
RTECS #:
Acute toxicity: none known
Primary irritant effect:
On the skin: none known
On the eye: not known; may be an irritant
Acute toxicity: none known
Primary irritant effect:
On the skin: none known
On the eye: not known; may be an irritant
SECTION XII:ECOLOGICAL INFORMATION
General notes: no data available
SECTION XIII:DISPOSAL CONSIDERATIONS
Dispose of in accordance with prevailing country, federal, state and local regulations
SECTION XIV:TRANSPORT INFORMATION
Proper shipping name: none
Non-Hazardous for transport: this substance is considered to be non-hazardous for transport
IATA class:
Proper shipping name: none
Non-Hazardous for transport: this substance is considered to be non-hazardous for transport
Non-Hazardous for transport: this substance is considered to be non-hazardous for transport
IATA class:
Proper shipping name: none
Non-Hazardous for transport: this substance is considered to be non-hazardous for transport
SECTION XV:REGULATORY INFORMATION
Code letter and hazard designation of product:
T: Toxic
EU Risk And Safety phrases:
S22: Do not breathe dust
S29: Do not empty into drains
S36/37/39: Wear suitable protective clothing, gloves, and eye/face protection
S38: In case of insufficient ventilation, wear suitable respiratory equipment
S45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
S53: Avoid exposure - obtain special instructions before use
R25: Toxic if swallowed
R48/22: Harmful: danger of serious damage to health by prolonged exposure if swallowed
R61: May cause harm to unborn child
T: Toxic
EU Risk And Safety phrases:
S22: Do not breathe dust
S29: Do not empty into drains
S36/37/39: Wear suitable protective clothing, gloves, and eye/face protection
S38: In case of insufficient ventilation, wear suitable respiratory equipment
S45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
S53: Avoid exposure - obtain special instructions before use
R25: Toxic if swallowed
R48/22: Harmful: danger of serious damage to health by prolonged exposure if swallowed
R61: May cause harm to unborn child
SECTION XVI:OTHER INFORMATION
The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty ofn merchantability or any other warranty, express or implied, with respect to such information. Users should make their own investigations to determine the suitability of the information for their particular purposes. Eton Bioscience Inc. shall not be held liable for any damages or other consequences resulting from handling or from contact with the above product.
END OF DATASHEET
