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- Pazopanib
Pazopanib
Pazopanib is a second-generation multitargeted tyrosine kinase inhibitor against VEGFR-1, 2 and 3, platelet-derived growth factor receptor (PDGFR)-a, PDGFR-ß and c-kit.
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| Molecular Formula: | C21H23N7O2S |
| Molecular Weight: | 473.52 g/mol |
| CAS Number: | 635702-64-6 |
| Appearance: | off white powder |
| Purity: | ≥99% |
| Storage: | -20ºC |
MATERIAL SAFETY DATA SHEET
TRADENAME: Pazopanib
DATE OF ISSUE:Feb 10.2011
SKU#:1100100102(10mg), 1100100252(25mg), 1100100502(50mg), 1100101002(100mg), 1100102002(200mg)
SECTION I:PRODUCT AND MANUFACTURER INFORMATION
TRADE NAME: Pazopanib
Supplier: Eton Bioscience Inc., 5820 Oberlin Drive, Suite 108, San Diego, CA 92121
Information Telephone:800.758.1630
Emergency Telephone: 800.758.1630
SECTION II: COMPOSITION / INFORMATION ON INGREDIENTS
Chemical Name: 5-[[4-[2,3-Dimethyl-2H-indazol-6-yl]methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide
Synonyms :
Hazardous Ingredient: Pazopanib
Molecular Weight: 473.98
Molecular Formula: C21H23N7O2S
Molecular Weight: 473.98
Molecular Formula: C21H23N7O2S
CAS Number: 635702-64-6
SECTION III:HAZARD IDENTIFICATION
Hazard Description: Reproductive effector; pharmaceutical agent
Exposure may result in adverse effects on the development of human offspring
Exposure may produce adverse effects on human fertility
Exposure may cause irritation of the respiratory tract, eye, and skin and allergic respiratory and skin reactions such as rash, hives, and itching
Exposure may result in adverse effects on the development of human offspring
Exposure may produce adverse effects on human fertility
Exposure may cause irritation of the respiratory tract, eye, and skin and allergic respiratory and skin reactions such as rash, hives, and itching
SECTION IV:FIRST AID MEASURES
After Inhalation: If inhaled, remove to fresh air; if breathing is difficult, give oxygen; if breathing stops, give artificial respiration
After skin contact: flush with copious amounts of water; remove contaminated clothing and shoes; call a physician
After eye contact: check for and remove contact lenses and flush with copious amounts of water; assure adequate flushing by separating the eyelids with fingers; call a physician
After swallowing: if swallowed, wash out mouth with copious amounts of water; call a physician
After skin contact: flush with copious amounts of water; remove contaminated clothing and shoes; call a physician
After eye contact: check for and remove contact lenses and flush with copious amounts of water; assure adequate flushing by separating the eyelids with fingers; call a physician
After swallowing: if swallowed, wash out mouth with copious amounts of water; call a physician
SECTION V:FIREFIGHTING MEASURES
Suitable extinguishing agents: water spray, carbon dioxide, dry chemical powder or foam
Protective equipment: wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Unusual fire hazard: may emit toxic fumes under fire conditions such as carbon monoxide, etc.
Protective equipment: wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Unusual fire hazard: may emit toxic fumes under fire conditions such as carbon monoxide, etc.
SECTION VI:ACCIDENTAL RELEASE MEASURES
Person-related safety precautions: cordon off area of spill; wear self-contained breathing apparatus, protective clothing and heavy rubber gloves
Measures for cleaning/collecting: absorb solutions with finely-powdered liquid-binding material (diatomite, universal binders); decontaminate surfaces and equipment by scrubbing with alcohol; dispose of contaminated material according to Section 13
Measures for cleaning/collecting: absorb solutions with finely-powdered liquid-binding material (diatomite, universal binders); decontaminate surfaces and equipment by scrubbing with alcohol; dispose of contaminated material according to Section 13
SECTION VII:HANDLING AND STORAGE
Information for safe handling: avoid inhalation and contact with skin, eyes, and clothing; material may be an irritant
Storage: Store solid and solutions at -20C
SECTION VIII:EXPOSURE CONTROLS / PERSONAL PROTECTION
Personal protective equipment as follows:
Breathing equipment: NIOSH/MSHA-approved respirator
Protection of hands: chemical-resistant rubber gloves
Eye protection: chemical safety goggles
Breathing equipment: NIOSH/MSHA-approved respirator
Protection of hands: chemical-resistant rubber gloves
Eye protection: chemical safety goggles
SECTION IX:PHYSICAL AND CHEMICAL PROPERTIES
Form: Crystalline solid; granular or powder
Color: White to off-white
Odor: none
Melting point/Melting range:
Danger of explosion: none
Solubility in / Miscibility with water:
Solvent content: none
Organic solvents: soluble in DMSO
Color: White to off-white
Odor: none
Melting point/Melting range:
Danger of explosion: none
Solubility in / Miscibility with water:
Solvent content: none
Organic solvents: soluble in DMSO
SECTION X:STABILITY AND REACTIVITY
Stability: stable if stored as directed; avoid strong oxidizing agents
Thermal decomposition / conditions to be avoided: protect from light and heat
Dangerous products of decomposition: thermal decomposition may produce toxic gases such as carbon monoxide, carbon dioxide, and nitrogen oxides
Thermal decomposition / conditions to be avoided: protect from light and heat
Dangerous products of decomposition: thermal decomposition may produce toxic gases such as carbon monoxide, carbon dioxide, and nitrogen oxides
SECTION XI:TOXICOLOGICAL INFORMATION
RTECS No: not available
Acute toxicity: not known
Primary irritant effect:
On the skin: not known; may be an irritant; allergic skin reactions might occur following repeated contact
On the eye: not known; may be an irritant
Inhalation: not known; may be an irritant
Ingestion: not known; risk of toxicity in developing human offspring might occur; risk of impaired fertility in humans might occur
Acute toxicity: not known
Primary irritant effect:
On the skin: not known; may be an irritant; allergic skin reactions might occur following repeated contact
On the eye: not known; may be an irritant
Inhalation: not known; may be an irritant
Ingestion: not known; risk of toxicity in developing human offspring might occur; risk of impaired fertility in humans might occur
SECTION XII:ECOLOGICAL INFORMATION
General notes: no data available
SECTION XIII:DISPOSAL CONSIDERATIONS
Dispose of in accordance with prevailing country, federal, state and local regulations
SECTION XIV:TRANSPORT INFORMATION
DOT:
Proper shipping name: none
Non-Hazardous for transport: this substance is considered to be non-hazardous for transport
IATA class:
Proper shipping name: none
Non-Hazardous for transport: this substance is considered to be non-hazardous for transport
Proper shipping name: none
Non-Hazardous for transport: this substance is considered to be non-hazardous for transport
IATA class:
Proper shipping name: none
Non-Hazardous for transport: this substance is considered to be non-hazardous for transport
SECTION XV:REGULATORY INFORMATION
Code letter and hazard designation of product:
EU Risk And Safety phrases:
R62: Possible risk of impaired fertility
R63: Possible risk of harm to the unborn child
S22: Do not breathe dust
S36/37: Wear suitable protective clothing and gloves
S53: Avoid exposure - obtain special instructions before use
EU Risk And Safety phrases:
R62: Possible risk of impaired fertility
R63: Possible risk of harm to the unborn child
S22: Do not breathe dust
S36/37: Wear suitable protective clothing and gloves
S53: Avoid exposure - obtain special instructions before use
SECTION XVI:OTHER INFORMATION
The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty ofn merchantability or any other warranty, express or implied, with respect to such information. Users should make their own investigations to determine the suitability of the information for their particular purposes. Eton Bioscience Inc. shall not be held liable for any damages or other consequences resulting from handling or from contact with the above product.
END OF DATASHEET
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