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- Doxorubicin HCl
Doxorubicin HCl
Doxorubicin, Adriamycin, 14-hydroxydaunomycin, NSC-123127, FI-106. Anthracycline antibiotic isolated from Streptomyces peucetius var caesius. DNA intercalator.
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| Molecular Formula: | C27H29NO11 |
| Molecular Weight: | 579.98 g/mol |
| CAS Number: | 25316-40-9 |
| Solubility: | soluble in DMSO at 100 mg/mL; very poorly soluble in ethanol |
| Purity: | ≥98% |
| Applications: | Anti-neoplastic |
| Storage: | -20C |
Reference
Merck Index (12ed) 3495, pp581-582
MATERIAL SAFETY DATA SHEET
TRADENAME:Doxorubicin
DATE OF ISSUE:Feb 10.2011
DATE OF ISSUE:Feb 10.2011
SKU#: 1100080102(10mg), 1100080502(50mg)
SECTION I:PRODUCT AND MANUFACTURER INFORMATION
TRADE NAME:Doxorubicin
Supplier: Eton Bioscience Inc., 5820 Oberlin Drive, Suite 108, San Diego, CA 92121
Supplier: Eton Bioscience Inc., 5820 Oberlin Drive, Suite 108, San Diego, CA 92121
Information Telephone:800.758.1630
Emergency Telephone: 800.758.1630
SECTION II: COMPOSITION / INFORMATION ON INGREDIENTS
Chemical Name: (7S,9S)-7-(4-amino-5-hydroxy-6-methyloxan-2-yl)oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione Hydrochloride
Synonyms:
Hazardous Ingredient: Doxorubicin
Molecular Weight: 579.98
Molecular Formula: C27H29NO11•HCl
Molecular Weight: 579.98
Molecular Formula: C27H29NO11•HCl
CAS Number:25316-40-9
SECTION III:HAZARD IDENTIFICATION
Hazard Description:Toxic
RTECS Substance category: Tumorigen; Drug; Mutagen; Natural Product; Human Data; Reproductive Effector
May be harmful or fatal if inhaled, swallowed, or absorbed through skin
Exposure may result in damage to the heart, skin, eyes, respiratory system, digestive system, endocrine system, and urinary system
Ingestion may cause complete alopecia (hair loss), onycholysis (separation of nail from nail bed), nail bed hyperpigmentation, rash, itching, urticaria (hives), photosensitivity, acute nausea, vomiting, mucositis (inflammation and ulceration of the mucous membranes lining the digestive tract), anorexia, abdominal pain, dehydration, diarrhea, fever, chills, seizure and coma
Exposure may cause tumors and adversely affect fertility and newborn and breastfed infants
RTECS Substance category: Tumorigen; Drug; Mutagen; Natural Product; Human Data; Reproductive Effector
May be harmful or fatal if inhaled, swallowed, or absorbed through skin
Exposure may result in damage to the heart, skin, eyes, respiratory system, digestive system, endocrine system, and urinary system
Ingestion may cause complete alopecia (hair loss), onycholysis (separation of nail from nail bed), nail bed hyperpigmentation, rash, itching, urticaria (hives), photosensitivity, acute nausea, vomiting, mucositis (inflammation and ulceration of the mucous membranes lining the digestive tract), anorexia, abdominal pain, dehydration, diarrhea, fever, chills, seizure and coma
Exposure may cause tumors and adversely affect fertility and newborn and breastfed infants
SECTION IV:FIRST AID MEASURES
After Inhalation: If inhaled, remove to fresh air; if breathing is difficult, give oxygen; if breathing stops, give artificial respiration
After skin contact: flush with copious amounts of water; remove contaminated clothing and shoes; call a physician
After eye contact: check for and remove contact lenses and flush with copious amounts of water; assure adequate flushing by separating the eyelids with fingers; call a physician
After swallowing: if swallowed, wash out mouth with copious amounts of water; call a physician
After skin contact: flush with copious amounts of water; remove contaminated clothing and shoes; call a physician
After eye contact: check for and remove contact lenses and flush with copious amounts of water; assure adequate flushing by separating the eyelids with fingers; call a physician
After swallowing: if swallowed, wash out mouth with copious amounts of water; call a physician
SECTION V:FIREFIGHTING MEASURES
Suitable extinguishing agents: water spray, carbon dioxide, dry chemical powder or foam
Protective equipment: wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Unusual fire hazard: may emit toxic fumes under fire conditions such as carbon monoxide, etc
Protective equipment: wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Unusual fire hazard: may emit toxic fumes under fire conditions such as carbon monoxide, etc
SECTION VI:ACCIDENTAL RELEASE MEASURES
Person-related safety precautions: cordon off area of spill; wear self-contained breathing apparatus, protective clothing and heavy rubber gloves
Measures for cleaning/collecting: absorb solutions with finely-powdered liquid-binding material (diatomite, universal binders); decontaminate surfaces and equipment by scrubbing with alcohol; dispose of contaminated material according to Section 13
Measures for cleaning/collecting: absorb solutions with finely-powdered liquid-binding material (diatomite, universal binders); decontaminate surfaces and equipment by scrubbing with alcohol; dispose of contaminated material according to Section 13
SECTION VII:HANDLING AND STORAGE
Information for safe handling: avoid inhalation and contact with skin, eyes, and clothing; material may be an irritant
Storage:Store solid and solutions at -20C
SECTION VIII:EXPOSURE CONTROLS / PERSONAL PROTECTION
Personal protective equipment as follows:
Breathing equipment: NIOSH/MSHA-approved respirator
Protection of hands: chemical-resistant rubber gloves
Eye protection: chemical safety goggles
Breathing equipment: NIOSH/MSHA-approved respirator
Protection of hands: chemical-resistant rubber gloves
Eye protection: chemical safety goggles
SECTION IX:PHYSICAL AND CHEMICAL PROPERTIES
Form: crystalline solid; granular or powder
Color: orange
Odor: none
Melting point/Melting range: not determined
Danger of explosion: none
Solubility in / Miscibility with water: soluble in water at 10 mg/mL with slight warming; buffers, serum, or other additives may increase or decrease the aqueous solubility
Solvent content:
Organic solvents: soluble in DMSO at 100 mg/mL; very poorly soluble in ethanol
Color: orange
Odor: none
Melting point/Melting range: not determined
Danger of explosion: none
Solubility in / Miscibility with water: soluble in water at 10 mg/mL with slight warming; buffers, serum, or other additives may increase or decrease the aqueous solubility
Solvent content:
Organic solvents: soluble in DMSO at 100 mg/mL; very poorly soluble in ethanol
SECTION X:STABILITY AND REACTIVITY
Stability: stable if stored as directed; Avoid strong oxidizing agents.
Thermal decomposition / conditions to be avoided: protect from light and heat
Dangerous products of decomposition: thermal decomposition may produce toxic gases such as carbon monoxide, carbon dioxide, and nitrogen oxides
Thermal decomposition / conditions to be avoided: protect from light and heat
Dangerous products of decomposition: thermal decomposition may produce toxic gases such as carbon monoxide, carbon dioxide, and nitrogen oxides
SECTION XI:TOXICOLOGICAL INFORMATION
RTECS No:
Acute toxicity: intravenous toxicity (TDLo): 12mg/kg (human); intraperitoneal toxicity (LD50): 16030µg/kg (rat); subcutaneous toxicity (LD50): 21840µg/kg (rat); intravenous toxicity (LD50): 12510µg/kg (rat); intramuscular toxicity (LD50): 16mg/kg (rat); oral toxicity (LD50): 698mg/kg (mouse); intraperitoneal toxicity (LD50): 11160µg/kg (mouse); subcutaneous toxicity (LD50): 7678µg/kg (mouse); intramuscular toxicity (LD50): 13700µg/kg (mouse); intravenous toxicity (LD50): 5980µg/kg (rabbit)
Primary irritant effect:
On the skin: irritant; harmful if absorbed through the skin
On the eye: irritant; harmful in contact with eyes
Inhalation: irritant; harmful if inhaled
Ingestion: harmful if swallowed
Acute toxicity: intravenous toxicity (TDLo): 12mg/kg (human); intraperitoneal toxicity (LD50): 16030µg/kg (rat); subcutaneous toxicity (LD50): 21840µg/kg (rat); intravenous toxicity (LD50): 12510µg/kg (rat); intramuscular toxicity (LD50): 16mg/kg (rat); oral toxicity (LD50): 698mg/kg (mouse); intraperitoneal toxicity (LD50): 11160µg/kg (mouse); subcutaneous toxicity (LD50): 7678µg/kg (mouse); intramuscular toxicity (LD50): 13700µg/kg (mouse); intravenous toxicity (LD50): 5980µg/kg (rabbit)
Primary irritant effect:
On the skin: irritant; harmful if absorbed through the skin
On the eye: irritant; harmful in contact with eyes
Inhalation: irritant; harmful if inhaled
Ingestion: harmful if swallowed
SECTION XII:ECOLOGICAL INFORMATION
General notes: no data available
SECTION XIII:DISPOSAL CONSIDERATIONS
Dispose of in accordance with prevailing country, federal, state and local regulations
SECTION XIV:TRANSPORT INFORMATION
DOT:
Proper shipping name: none
Non-Hazardous for transport: this substance is considered to be non-hazardous for transport
IATA class:
Proper shipping name: none
Non-Hazardous for transport: this substance is considered to be non-hazardous for transport
Proper shipping name: none
Non-Hazardous for transport: this substance is considered to be non-hazardous for transport
IATA class:
Proper shipping name: none
Non-Hazardous for transport: this substance is considered to be non-hazardous for transport
SECTION XV:REGULATORY INFORMATION
Code letter and hazard designation of product:
T: Toxic
EU Risk And Safety phrases:
S22: Do not breathe dust
S24/25: Avoid contact with skin and eyes
S28: After contact with skin, wash immediately with plenty of water
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible)
S53: Avoid exposure - obtain special instructions before use
R22: Harmful if swallowed
R37/38: Irritating to respiratory system and skin
R41: Risk of serious damage to eyes
R45: May cause cancer
R46: May cause heritable genetic damage
R62: Possible risk of impaired fertility
R63: Possible risk of harm to the unborn child
R68: Possible risk of irreversible effects
T: Toxic
EU Risk And Safety phrases:
S22: Do not breathe dust
S24/25: Avoid contact with skin and eyes
S28: After contact with skin, wash immediately with plenty of water
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible)
S53: Avoid exposure - obtain special instructions before use
R22: Harmful if swallowed
R37/38: Irritating to respiratory system and skin
R41: Risk of serious damage to eyes
R45: May cause cancer
R46: May cause heritable genetic damage
R62: Possible risk of impaired fertility
R63: Possible risk of harm to the unborn child
R68: Possible risk of irreversible effects
SECTION XVI:OTHER INFORMATION
The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information.Eton Bioscience Inc. shall not be held liable for any damages or other consequences resulting from handling or from contact with the above product.
END OF DATASHEET
